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1

Caspases: key mediators of apoptosis

Nancy A. Thornberry

Journal:

Chemistry & Biology

Année:

1998

Langue:

english

Fichier:

PDF, 4.63 MB

english, 1998

2

Purification and catalytic properties of human caspase family members

Garcia-Calvo, Margarita, Peterson, Erin P, Rasper, Dita M, Vaillancourt, John P, Zamboni, Robert, Nicholson, Donald W, Thornberry, Nancy A

Journal:

Cell Death & Differentiation

Année:

1999

Langue:

english

Fichier:

PDF, 144 KB

english, 1999

3

Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils

Darshak M Sanghavi, Marcus Thelen, Nancy A Thornberry, Livia Casciola-Rosen, Antony Rosen

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 248 KB

english, 1998

4

Human ICE/CED-3 Protease Nomenclature

Emad S Alnemri, David J Livingston, Donald W Nicholson, Guy Salvesen, Nancy A Thornberry, Winnie W Wong, Junying Yuan

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 90 KB

english, 1996

5

Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

Marie Mancini, Carolyn E. Machamer, Sophie Roy, Donald W. Nicholson, Nancy A. Thornberry, Livia A. Casciola-Rosen and Antony Rosen

Journal:

The Journal of Cell Biology

Année:

2000

Langue:

english

Fichier:

PDF, 2.98 MB

english, 2000

6

ChemInform Abstract: Discovery of Potent, Selective Human Granzyme B Inhibitors That Inhibit CTL Mediated Apoptosis.

Christopher A. Willoughby, Herbert G. Bull, Margarita Garcia-Calvo, Joanne Jiang, Kevin T. Chapman, Nancy A. Thornberry

Journal:

Année:

2002

Fichier:

PDF, 27 KB

2002

7

Heterocycle-Fused Cyclohexylglycine Derivatives as Novel Dipeptidyl Peptidase-IV Inhibitors.

Anthony Mastracchio, Emma R. Parmee, Barbara Leiting, Frank Marsilio, Reshma Patel, Nancy A. Thornberry, Ann E. Weber, Scott D. Edmondson

Journal:

Année:

2004

Fichier:

PDF, 75 KB

2004

8

Diastereoselective Synthesis and Configuration-Dependent Activity of (3-Substituted-cycloalkyl)glycine Pyrrolidides and Thiazolidides as Dipeptidyl Peptidase IV Inhibitors.

Wallace T. Ashton, Hong Dong, Rosemary M. Sisco, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. Thornberry, Ann E. Weber

Journal:

Année:

2004

Fichier:

PDF, 70 KB

2004

9

Identification of peptidase substrates in human plasma by FTMS based differential mass spectrometry

Nathan A. Yates, Ekaterina G. Deyanova, Wayne Geissler, Matthew C. Wiener, Jeffrey R. Sachs, Kenny K. Wong, Nancy A. Thornberry, Ranabir Sinha Roy, Robert E. Settlage, Ronald C. Hendrickson

Journal:

International Journal of Mass Spectrometry

Année:

2007

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2007

10

Inhibition of interleukin-1β converting enzyme by N-Acyl-aspartic acid ketones

Adnan M.M. Mjalli, Kevin T. Chapman, Justin J. Zhao, Nancy A. Thornberry, Erin P. Peterson, Malcolm MacCoss

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 190 KB

english, 1995

11

Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole

Wallace T. Ashton, Rosemary M. Sisco, Hong Dong, Kathryn A. Lyons, Huaibing He, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 145 KB

english, 2005

12

Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors

Ying-Duo Gao, Dennis Feng, Robert P. Sheridan, Giovanna Scapin, Sangita B. Patel, Joseph K. Wu, Xiaoping Zhang, Ranabir Sinha-Roy, Nancy A. Thornberry, Ann E. Weber, Tesfaye Biftu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 182 KB

english, 2007

13

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Jason M. Cox, Bart Harper, Anthony Mastracchio, Barbara Leiting, Ranabir Sinha Roy, Reshma A. Patel, Joseph K. Wu, Kathryn A. Lyons, Huaibing He, Shiyao Xu, Bing Zhu, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 160 KB

english, 2007

14

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes

Ping Chen, Charles G. Caldwell, Robert J. Mathvink, Barbara Leiting, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 148 KB

english, 2007

15

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design

Gui-Bai Liang, Xiaoxia Qian, Tesfaye Biftu, Suresh Singh, Ying-Duo Gao, Giovanna Scapin, Sangita Patel, Barbara Leiting, Reshma Patel, Joseph Wu, Xiaoping Zhang, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 427 KB

english, 2008

16

Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors

Ping Chen, Charles G. Caldwell, Wallace Ashton, Joseph K. Wu, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2011

17

Activated ketones as potent reversible inhibitors of interleukin-Iβ converting enzyme

Adnan M.M. Mjalli, Kevin T. Chapman, Malcolm MacCoss, Nancy A. Thornberry, Erin P. Peterson

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1994

Langue:

english

Fichier:

PDF, 188 KB

english, 1994

18

Phenylalkyl ketones as potent reversible inhibitors of interleukin-1β converting enzyme

Adnan M.M. Mjalli, Kevin T. Chapman, Malcolm MacCoss, Nancy A. Thornberry

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 210 KB

english, 1993

19

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis

Christopher A. Willoughby, Herbert G. Bull, Margarita Garcia-Calvo, Joanne Jiang, Kevin T. Chapman, Nancy A. Thornberry

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 118 KB

english, 2002

20

Nicotinyl aspartyl ketones as inhibitors of caspase-3

Elise Isabel, W.Cameron Black, Christopher I Bayly, Erich L Grimm, Marc K Janes, Daniel J McKay, Donald W Nicholson, Dita M Rasper, Johanne Renaud, Sophie Roy, John Tam, Nancy A Thornberry, John P Vai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 168 KB

english, 2003

21

Interleukin-1βconverting enzyme: A novel cysteine protease required for IL-1β production and implicated in programmed cell death

Nancy A. Thornberry, Susan M. Molineaux

Journal:

Protein Science

Année:

1995

Langue:

english

Fichier:

PDF, 2.73 MB

english, 1995

22

Interleukin-1β-converting enzyme and related proteases as potential targets in inflammation and apoptosis

Nancy A. Thornberry, Douglas K. Miller, Donald W. Nicholson

Journal:

Perspectives in Drug Discovery and Design

Année:

1995

Langue:

english

Fichier:

PDF, 784 KB

english, 1995

23

Inhibition of interleukin-1β converting enzyme by N-acyl-aspartyl aryloxymethyl ketones

Adnan M.M. Mjalli, Justin J. Zhao, Kevin T. Chapman, Nancy A. Thornberry, Erin P. Peterson, Malcolm MacCoss, William K. Hagmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 271 KB

english, 1995

24

Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors

Wallace T. Ashton, Hong Dong, Rosemary M. Sisco, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 241 KB

english, 2004

25

Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors

Jinyou Xu, Hyun O. Ok, Edward J. Gonzalez, Lawrence F. Colwell Jr., Bahanu Habulihaz, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Nancy A. Thornberry

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 258 KB

english, 2004

26

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors

Jinyou Xu, Lan Wei, Robert Mathvink, Jiafang He, You-Jung Park, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 113 KB

english, 2005

27

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

Jennifer Rotonda, Margarita Garcia-Calvo, Herb G Bull, Wayne M Geissler, Brian M McKeever, Christopher A Willoughby, Nancy A Thornberry, Joseph W Becker

Journal:

Chemistry & Biology

Année:

2001

Langue:

english

Fichier:

PDF, 1020 KB

english, 2001

28

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Thornberry, Nancy A., Bull, Herbert G., Calaycay, Jimmy R., Chapman, Kevin T., Howard, Andrew D., Kostura, Matthew J., Miller, Douglas K., Molineaux, Susan M., Weidner, Jeffrey R., Aunins, John

Journal:

Année:

1992

Fichier:

PDF, 1.24 MB

1992

29

Key mediator takes shape

Thornberry, Nancy A.

Journal:

Année:

1994

Fichier:

PDF, 278 KB

1994

30

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Nicholson, Donald W., Ali, Ambereen, Thornberry, Nancy A., Vaillancourt, John P., Ding, Connie K., Gallant, Michel, Gareau, Yves, Griffin, Patrick R., Labelle, Marc, Lazebnik, Yuri A.

Journal:

Année:

1995

Fichier:

PDF, 1.70 MB

1995

31

Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets

Deena Waddleton, Weizhen Wu, Yue Feng, Chris Thompson, Michael Wu, Yun-Ping Zhou, Andrew Howard, Nancy Thornberry, Jing Li, Joseph A. Mancini

Journal:

Biochemical Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 659 KB

english, 2008

32

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes

James Mu, Aleksandr Petrov, George J. Eiermann, John Woods, Yun-Ping Zhou, Zhihua Li, Emanuel Zycband, Yue Feng, Lan Zhu, Ranabir Sinha Roy, Andrew D. Howard, Cai Li, Nancy A. Thornberry, Bei B. Zhang

Journal:

European Journal of Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2009

33

Caspases: killer proteases

Donald W. Nicholson, Nancy A. Thornberry

Journal:

Trends in Biochemical Sciences

Année:

1997

Langue:

english

Fichier:

PDF, 2.91 MB

english, 1997

34

A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE)

Thomas A. Rano, Tracy Timkey, Erin P. Peterson, Jennifer Rotonda, Donald W. Nicholson, Joseph W. Becker, Kevin T. Chapman, Nancy A. Thornberry

Journal:

Chemistry & Biology

Année:

1997

Langue:

english

Fichier:

PDF, 2.48 MB

english, 1997

35

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents

Jonathan W. Day, Vasily Gelfanov, David Smiley, Paul E. Carrington, George Eiermann, Gary Chicchi, Mark D. Erion, Jas Gidda, Nancy A. Thornberry, Matthias H. Tschöp, Donald J. Marsh, Ranabir SinhaRoy,

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 504 KB

english, 2012

36

Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

Felipe Andrade, Sophie Roy, Donald Nicholson, Nancy Thornberry, Antony Rosen, Livia Casciola-Rosen

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 271 KB

english, 1998

37

Adenovirus L4-100K Assembly Protein Is a Granzyme B Substrate that Potently Inhibits Granzyme B-Mediated Cell Death

Felipe Andrade, Herbert G Bull, Nancy A Thornberry, Gary W Ketner, Livia A Casciola-Rosen, Antony Rosen

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 369 KB

english, 2001

38

Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)

Nancy A. Thornberry, Baptist Gallwitz

Journal:

Best Practice & Research Clinical Endocrinology & Metabolism

Année:

2009

Langue:

english

Fichier:

PDF, 250 KB

english, 2009

39

Kinetic Effects of ATP and Two Cellular Stimulatory Components on Human Leukocyte 5-Lipoxygenase

CAROL A. ROUZER, NANCY A. THORNBERRY, HERBERT G. BULL

Journal:

Annals of the New York Academy of Sciences

Année:

1988

Langue:

english

Fichier:

PDF, 563 KB

english, 1988

40

The IL-1β Converting Enzyme as a Therapeutic Target

DOUGLAS K. MILLER, JIMMY R. CALAYCAY, KEVIN T. CHAPMAN, ANDREW D. HOWARD, MATTHEW J. KOSTURA, SUSAN M. MOLINEAUX, NANCY A. THORNBERRY

Journal:

Annals of the New York Academy of Sciences

Année:

1993

Langue:

english

Fichier:

PDF, 1.19 MB

english, 1993

41

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

Marie Mancini, Donald W. Nicholson, Sophie Roy, Nancy A. Thornberry, Erin P. Peterson, Livia A. Casciola-Rosen and Antony Rosen

Journal:

The Journal of Cell Biology

Année:

1998

Langue:

english

Fichier:

PDF, 2.90 MB

english, 1998

42

Letters to the Editor

Joel Margolis, Mary Thornberry, Lewis A. Dexter, Richard E. Bissell, J. Michael Carmichael, Arnold Beichman, Sixto Carlos, Jr., Nancy Zingale and Mario A. Rivera

Journal:

Année:

1983

Langue:

english

Fichier:

PDF, 728 KB

english, 1983

43

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

Thornberry, Nancy A., Peterson, Erin P., Zhao, Justin J., Howard, Andrew D., Griffin, Patrick R., Chapman, Kevin T.

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 1.37 MB

english, 1994

44

A Synthetic Inhibitor of Interleukin-lβ Converting Enzyme Prevents Endotoxin-Induced Interleukin-lβ Production In Vitro and In Vivo

FLETCHER, DANIEL S., AGARWAL, LILY, CHAPMAN, KEVIN T., CHIN, JAYNE, EGGER, LINDA A., LIMJUCO, GUADALUPE, LUELL, SILVI, MacINTYRE, D. EUAN, PETERSON, ERIN P., THORNBERRY, NANCY A., KOSTURA, MATHEW J.

Journal:

Journal of Interferon & Cytokine Research

Année:

1995

Langue:

english

Fichier:

PDF, 2.00 MB

english, 1995

45

Glucagon-like Peptide 1–Based Drugs and Pancreatic Safety

Brodovicz, Kimberly G., Engel, Samuel S., Thornberry, Nancy A.

Journal:

JAMA Internal Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 70 KB

english, 2013

46

Discovery of JANUVIA™ (Sitagliptin), a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type2 Diabetes.

Thornberry, Nancy, Weber, Ann

Journal:

Current Topics in Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 147 KB

english, 2007

47

[Methods in Enzymology] Apoptosis Volume 322 || Determination of Caspase Specificities Using a Peptide Combinatorial Library

Thornberry, Nancy A.

Année:

2000

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2000

48

Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 Under Pathological Conditions

Shin-Jung Kang, Suyue Wang, Hideaki Hara, Erin P. Peterson, Shobu Namura, Sepideh Amin-Hanjani, Zhihong Huang, Anu Srinivasan, Kevin J. Tomaselli, Nancy A. Thornberry, Michael A. Moskowitz and Junying

Journal:

The Journal of Cell Biology

Année:

2000

Langue:

english

Fichier:

PDF, 3.22 MB

english, 2000

49

[Advances in Pharmacology] Apoptosls - Pharmacological Implications and Therapeutic Opportunities Volume 41 || Control of Apoptosis by Proteases

Thornberry, Nancy A.

Année:

1997

Langue:

english

Fichier:

PDF, 1.43 MB

english, 1997

50

Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII

LEITING, Barbara, PRYOR, KellyAnn D., WU, Joseph K., MARSILIO, Frank, PATEL, Reshma A., CRAIK, Charles S., ELLMAN, Jonathan A., CUMMINGS, Richard T., THORNBERRY, Nancy A.

Journal:

Biochemical Journal

Année:

2003

Langue:

english

Fichier:

PDF, 182 KB

english, 2003